@article{d209e671422a42deb9dd4a216b7a82d8,
title = "A reassignment of (-)-mycothiazole and the isolation of a related Diol",
abstract = "A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.",
keywords = "Alcohols, Animals, Antineoplastic Agents, Bridged Bicyclo Compounds, Heterocyclic, Drug Screening Assays, Antitumor, Epothilones, Molecular Structure, Polyketide Synthases, Porifera, Stereoisomerism, Thiazoles, Thiazolidines, Vanuatu",
author = "Sonnenschein, \{Rachel N.\} and Johnson, \{Tyler A.\} and Karen Tenney and Valeriote, \{Frederick A.\} and Phillip Crews",
year = "2006",
month = jan,
day = "10",
doi = "10.1021/np0503597",
language = "American English",
volume = "69",
pages = "145--147",
journal = "Journal of Natural Products",
number = "1",
}