Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum

Roland A. Cooper; Michael T. Ferdig; Xin-zhuan Su; Lyann M. B. Ursos; Jiabing Mu; Takashi Nomura; David A. Fidock; Paul D. Roepe; Thomas E. Wellems

doi:<a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>

Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum

Roland A. Cooper
, Michael T. Ferdig
, Xin-zhuan Su
, Lyann M. B. Ursos
, Jiabing Mu
, Takashi Nomura
, David A. Fidock
, Paul D. Roepe
, Thomas E. Wellems

National Institute of Allergy and Infectious Diseases, National Institutes of Health
Tumor Biology Program, Lombardi Cancer Center, Georgetown University
Institute of Pathology, Case Western Reserve University

Research output: Contribution to journal › Article › peer-review

Original language	American English
Pages (from-to)	35-42
Number of pages	8
Journal	Molecular Pharmacology
Volume	61
Issue number	1
DOIs	https://doi.org/<a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>
State	Published - 2002
Externally published	Yes

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	Z01AI000483

ASJC Scopus Subject Areas

Molecular Medicine
Pharmacology

Disciplines

Parasitology

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<a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>License: Unspecified

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Cooper, R. A., Ferdig, M. T., Su, X., Ursos, L. M. B., Mu, J., Nomura, T., Fidock, D. A., Roepe, P. D., & Wellems, T. E. (2002). Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum. Molecular Pharmacology, 61(1), 35-42. https://doi.org/<a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>

Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum. / Cooper, Roland A.; Ferdig, Michael T.; Su, Xin-zhuan et al.
In: Molecular Pharmacology, Vol. 61, No. 1, 2002, p. 35-42.

Research output: Contribution to journal › Article › peer-review

Cooper, RA, Ferdig, MT, Su, X, Ursos, LMB, Mu, J, Nomura, T, Fidock, DA, Roepe, PD & Wellems, TE 2002, 'Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum', Molecular Pharmacology, vol. 61, no. 1, pp. 35-42. https://doi.org/<a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>

Cooper RA, Ferdig MT, Su X, Ursos LMB, Mu J, Nomura T et al. Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum. Molecular Pharmacology. 2002;61(1):35-42. doi: <a href="http://molpharm.aspetjournals.org/content/61/1/35.short">10.1124/mol.61.1.35</a>

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AU - Mu, Jiabing

AU - Nomura, Takashi

AU - Fidock, David A.

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Alternative Mutations at Position 76 of the Vacuolar Transmembrane Protein PfCRT Are Associated with Chloroquine Resistance and Unique Stereospecific Quinine and Quinidine Responses in Plasmodium falciparum

Funding

ASJC Scopus Subject Areas

Disciplines

Access to Document

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