Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola

Quan-Xiang Wu, Mitchell S. Crews, Marija Drašković, Johann Sohn, Tyler A. Johnson, Karen Tenney, Frederick A Valeriote, Xiao-Jun Yao, Leonard F. Bjeldanes, Phillip Crews

Research output: Contribution to journalLetterpeer-review

Abstract

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.

Original languageAmerican English
Pages (from-to)4458-4461
Number of pages4
JournalOrganic Letters
Volume12
Issue number20
DOIs
StatePublished - Oct 15 2010
Externally publishedYes

Funding

FundersFunder number
National Cancer InstituteU01CA052955

    Keywords

    • Animals
    • Aspergillus
    • Cell Line
    • Cell Survival
    • Dipeptides
    • Humans
    • Mice
    • Models
    • Molecular
    • Molecular Structure

    Disciplines

    • Biochemistry
    • Natural Products Chemistry and Pharmacognosy

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