Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

Rozalia A. Dodean; Papireddy Kancharla; Yuexin Li; Victor Melendez; Lisa Read; Charles E. Bane; Brian Vesely; Mara Kreishman-Deitrick; Chad Black; Qigui Li; Richard J. Sciotti; Raul Olmeda; Thu-Lan Luong; Heather Gaona; Brittney Potter; Jason Sousa; Sean Marcsisin; Diana Caridha; Lisa Xie; Chau Vuong; Qiang Zeng; Jing Zhang; Ping Zhang; Hsiuling Lin; Kirk Butler; Norma Roncal; Lacy Gaynor-Ohnstad; Susan E. Leed; Christina Nolan; Stephanie J. Huezo; Stephanie A. Rasmussen; Melissa T. Stephens; John C. Tan; Roland A. Cooper; Martin J. Smilkstein; Sovitj Pou; Rolf W. Winter; Michael K. Riscoe; Jane X. Kelly

doi:10.1021/acs.jmedchem.8b01961

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

Rozalia A. Dodean, Papireddy Kancharla, Yuexin Li, Victor Melendez, Lisa Read, Charles E. Bane, Brian Vesely, Mara Kreishman-Deitrick, Chad Black, Qigui Li, Richard J. Sciotti, Raul Olmeda, Thu-Lan Luong, Heather Gaona, Brittney Potter, Jason Sousa, Sean Marcsisin, Diana Caridha, Lisa Xie, Chau VuongQiang Zeng, Jing Zhang, Ping Zhang, Hsiuling Lin, Kirk Butler, Norma Roncal, Lacy Gaynor-Ohnstad, Susan E. Leed, Christina Nolan, Stephanie J. Huezo, Stephanie A. Rasmussen, Melissa T. Stephens, John C. Tan, Roland A. Cooper, Martin J. Smilkstein, Sovitj Pou, Rolf W. Winter, Michael K. Riscoe, Jane X. Kelly

Department of Natural Sciences and Mathematics

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Default journal
Volume	62
DOIs	https://doi.org/10.1021/acs.jmedchem.8b01961
State	Published - Apr 11 2019

Keywords

Acridones
Animals
Antimalarials
Disease Models
Animal
Drug Discovery
Hep G2 Cells
Humans
Malaria
Mice
Plasmodium
Species Specificity
Structure-Activity Relationship

Disciplines

Life Sciences
Physical Sciences and Mathematics

Access to Document

10.1021/acs.jmedchem.8b01961License: Unspecified

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822569/

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Dodean, R. A., Kancharla, P., Li, Y., Melendez, V., Read, L., Bane, C. E., Vesely, B., Kreishman-Deitrick, M., Black, C., Li, Q., Sciotti, R. J., Olmeda, R., Luong, T.-L., Gaona, H., Potter, B., Sousa, J., Marcsisin, S., Caridha, D., Xie, L., ... Kelly, J. X. (2019). Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials. Default journal, 62. https://doi.org/10.1021/acs.jmedchem.8b01961

Dodean, RA, Kancharla, P, Li, Y, Melendez, V, Read, L, Bane, CE, Vesely, B, Kreishman-Deitrick, M, Black, C, Li, Q, Sciotti, RJ, Olmeda, R, Luong, T-L, Gaona, H, Potter, B, Sousa, J, Marcsisin, S, Caridha, D, Xie, L, Vuong, C, Zeng, Q, Zhang, J, Zhang, P, Lin, H, Butler, K, Roncal, N, Gaynor-Ohnstad, L, Leed, SE, Nolan, C, Huezo, SJ, Rasmussen, SA, Stephens, MT, Tan, JC, Cooper, RA, Smilkstein, MJ, Pou, S, Winter, RW, Riscoe, MK & Kelly, JX 2019, 'Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.', Default journal, vol. 62. https://doi.org/10.1021/acs.jmedchem.8b01961

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title = "Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.",

keywords = "Acridones, Animals, Antimalarials, Disease Models, Animal, Drug Discovery, Hep G2 Cells, Humans, Malaria, Mice, Plasmodium, Species Specificity, Structure-Activity Relationship",

author = "Dodean, {Rozalia A.} and Papireddy Kancharla and Yuexin Li and Victor Melendez and Lisa Read and Bane, {Charles E.} and Brian Vesely and Mara Kreishman-Deitrick and Chad Black and Qigui Li and Sciotti, {Richard J.} and Raul Olmeda and Thu-Lan Luong and Heather Gaona and Brittney Potter and Jason Sousa and Sean Marcsisin and Diana Caridha and Lisa Xie and Chau Vuong and Qiang Zeng and Jing Zhang and Ping Zhang and Hsiuling Lin and Kirk Butler and Norma Roncal and Lacy Gaynor-Ohnstad and Leed, {Susan E.} and Christina Nolan and Huezo, {Stephanie J.} and Rasmussen, {Stephanie A.} and Stephens, {Melissa T.} and Tan, {John C.} and Cooper, {Roland A.} and Smilkstein, {Martin J.} and Sovitj Pou and Winter, {Rolf W.} and Riscoe, {Michael K.} and Kelly, {Jane X.}",

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doi = "10.1021/acs.jmedchem.8b01961",

language = "American English",

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T1 - Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

AU - Dodean, Rozalia A.

AU - Kancharla, Papireddy

AU - Li, Yuexin

AU - Melendez, Victor

AU - Read, Lisa

AU - Bane, Charles E.

AU - Vesely, Brian

AU - Kreishman-Deitrick, Mara

AU - Black, Chad

AU - Li, Qigui

AU - Sciotti, Richard J.

AU - Olmeda, Raul

AU - Luong, Thu-Lan

AU - Gaona, Heather

AU - Potter, Brittney

AU - Sousa, Jason

AU - Marcsisin, Sean

AU - Caridha, Diana

AU - Xie, Lisa

AU - Vuong, Chau

AU - Zeng, Qiang

AU - Zhang, Jing

AU - Zhang, Ping

AU - Lin, Hsiuling

AU - Butler, Kirk

AU - Roncal, Norma

AU - Gaynor-Ohnstad, Lacy

AU - Leed, Susan E.

AU - Nolan, Christina

AU - Huezo, Stephanie J.

AU - Rasmussen, Stephanie A.

AU - Stephens, Melissa T.

AU - Tan, John C.

AU - Cooper, Roland A.

AU - Smilkstein, Martin J.

AU - Pou, Sovitj

AU - Winter, Rolf W.

AU - Riscoe, Michael K.

AU - Kelly, Jane X.

PY - 2019/4/11

Y1 - 2019/4/11

KW - Acridones

KW - Animals

KW - Antimalarials

KW - Disease Models

KW - Animal

KW - Drug Discovery

KW - Hep G2 Cells

KW - Humans

KW - Malaria

KW - Mice

KW - Plasmodium

KW - Species Specificity

KW - Structure-Activity Relationship

UR - https://scholar.dominican.edu/natural-sciences-and-mathematics-faculty-scholarship/32

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822569/

U2 - 10.1021/acs.jmedchem.8b01961

DO - 10.1021/acs.jmedchem.8b01961

M3 - Article

VL - 62

JO - Default journal

JF - Default journal

ER -

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

Keywords

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