Discovery of dual function acridones as a new antimalarial chemotype

Funding

Acknowledgements We thank D. Kyle for the gift of P. falciparum parasite Tm90-C2B, and the Malaria Research and Reference Resource Center for supplying P. falciparum parasites D6, Dd2 and 7G8. We thank A. P. Waters and C. J. Janse for the donation of GFP-labelled P. berghei strain ANKA. We thank L. Jones-Brando and R. Yolken for the cytotoxicity (HFF) data. We are grateful to A. Cornea for the confocal imaging. We thank K. Liebman, C. Hudson, S. Burgess and D. Peyton for compound characterization. We acknowledge financial support from the Merit Review Program of the Department of Veterans Affairs. United States patent applications have been filed by the US Department of Veterans Affairs to protect the intellectual property described in this report.