Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges.

Taro Amagata, Tyler A. Johnson, Robert H. Cichewicz, Karen Tenney, Susan L. Mooberry, Joseph Media, Matthew Edelstein, Frederick A. Valeriote, Phillip Crews

Research output: Contribution to journalArticlepeer-review

Original languageAmerican English
JournalDefault journal
Volume51
DOIs
StatePublished - Nov 27 2008
Externally publishedYes

Keywords

  • Animals
  • Bridged Bicyclo Compounds
  • Heterocyclic
  • Cell Line
  • Tumor
  • Cell Proliferation
  • Computer Simulation
  • Dose-Response Relationship
  • Drug
  • Drug Screening Assays
  • Antitumor
  • Heterocyclic Compounds
  • 2-Ring
  • Humans
  • Lactones
  • Magnetic Resonance Spectroscopy
  • Mice
  • Models
  • Chemical
  • Molecular Conformation
  • Porifera
  • Stereoisomerism
  • Thiazolidines

Disciplines

  • Biochemistry
  • Natural Products Chemistry and Pharmacognosy

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