@article{57a2fb8568e04db2bba74c77a5f8ae14,
title = "Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays",
abstract = "We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures at 72 h. Two of 53 isolates had nonsynonymous K13-propeller gene polymorphisms but did not have the mutations associated with resistance in Asia. Thus, we did not see evidence for artemisinin resistance in Uganda.",
keywords = "Artemisinin Resistance, Plasmodium falciparum",
author = "Cooper, \{Roland A.\} and Conrad, \{Melissa D.\} and Watson, \{Quentin D.\} and Huezo, \{Stephanie J.\} and Harriet Ninsiima and Patrick Tumwebaze and Nsobya, \{Samuel L.\} and Rosenthal, \{Philip J.\}",
note = "Copyright {\textcopyright} 2015, American Society for Microbiology. All Rights Reserved.",
year = "2015",
month = aug,
day = "1",
doi = "10.1128/AAC.00921-15",
language = "American English",
volume = "59",
pages = "5061--5064",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "1098-6596",
number = "8",
}