Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. infecting man

John B. Dame, Charles A. Yowell, Levi Omara-Opyene, Jane M. Carlton, Roland A. Cooper, Tang Li

Research output: Contribution to journalArticlepeer-review

Original languageAmerican English
Pages (from-to)1-12
Number of pages12
JournalMolecular and Biochemical Parasitology
Volume130
Issue number1
DOIs
StatePublished - Aug 2003
Externally publishedYes

Funding

This work was supported with funding from the National Institutes of Health, NIAID (R01 AI39211). Preliminary sequence data was obtained from the following institutes: (1) for P. vivax: The Institute for Genomic Research through the website at http://www.tigr.org . Sequencing of P. vivax was accomplished with support from the US Department of Defense through cooperative agreement with the US Army Medical Research and Materiel Command and by the Naval Medical Research Center, and by the National Institute for Allergy and Infectious Disease, National Institutes of Health; (2) for P. berghei and P. knowlesi: these sequence data were produced by the Pathogen Sequencing Unit at the Wellcome Trust Sanger Institute and were obtained from ftp://ftp.sanger.ac.uk/pub/pathogens/P_berghei/ and ftp://ftp.sanger.ac.uk/pub/pathogens/P_knowlesi/ , respectively.

FundersFunder number
National Institutes of Health
U.S. Department of Defense
National Institute of Allergy and Infectious DiseasesR01AI039211
Medical Research and Materiel Command
Naval Medical Research Center
Wellcome Trust

    Keywords

    • Plasmodium falciparum
    • Malaria
    • Plasmepsin
    • Aspartic proteinase
    • Food vacuole
    • Ortholog
    • Paralog
    • Multigene family

    Disciplines

    • Microbiology
    • Parasitology

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