Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

Michael J Palmer, Xiaoyi Deng, Shawn Watts, Goran Krilov, Aleksey Gerasyuto, Sreekanth Kokkonda, Farah El Mazouni, John White, Karen L White, Josefine Striepen, Jade Bath, Kyra A Schindler, Tomas Yeo, David M Shackleford, Sachel Mok, Ioanna Deni, Aloysus Lawong, Ann Huang, Gong Chen, Wen WangJaya Jayaseelan, Kasiram Katneni, Rahul Patil, Jessica Saunders, Shatrughan P Shahi, Rajesh Chittimalla, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Sergio Wittlin, Patrick K Tumwebaze, Philip J Rosenthal, Roland A. Cooper, Anna Caroline Campos Aguiar, Rafael V C Guido, Dhelio B Pereira, Nimisha Mittal, Elizabeth A Winzeler, Diana R Tomchick, Benoît Laleu, Jeremy N Burrows, Pradipsinh K Rathod, David A. Fidock, Susan A Charman, Margaret A Phillips

Research output: Contribution to journalArticlepeer-review

Original languageAmerican English
JournalDefault journal
Volume64
DOIs
StatePublished - May 13 2021

Keywords

  • Animals
  • Antimalarials
  • Dihydroorotate Dehydrogenase
  • Drug Design
  • Enzyme Inhibitors
  • Mice
  • Oxidoreductases Acting on CH-CH Group Donors
  • Plasmodium falciparum
  • Pyrroles
  • Structure-Activity Relationship

Disciplines

  • Medicinal and Pharmaceutical Chemistry
  • Parasitic Diseases

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