Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration

Tyler A. Johnson; Joseph D. Morris; David Coppage; Colon V. Cook; Lauren Persi; Marcos A. Ogarrio; Taylor C. Garcia; Nicole L. McIntosh; Erin P. McCauley; Joseph Media; Mani Maheshwari; Frederick A. Valeriote; Jiajiu Shaw; Phillip Crews

doi:10.1021/acsmedchemlett.9b00302

Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration

Tyler A. Johnson, Joseph D. Morris, David Coppage, Colon V. Cook, Lauren Persi, Marcos A. Ogarrio, Taylor C. Garcia, Nicole L. McIntosh, Erin P. McCauley, Joseph Media, Mani Maheshwari, Frederick A. Valeriote, Jiajiu Shaw, Phillip Crews

Department of Natural Sciences and Mathematics

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	ACS Medicinal Chemistry Letters
Volume	11
DOIs	https://doi.org/10.1021/acsmedchemlett.9b00302
State	Published - Jan 2 2020

Keywords

Mycothiazole
Cytotoxic
Picomolar

Disciplines

Medicinal Chemistry and Pharmaceutics

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10.1021/acsmedchemlett.9b00302License: Unspecified

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Cite this

Johnson, T. A., Morris, J. D., Coppage, D., Cook, C. V., Persi, L., Ogarrio, M. A., Garcia, T. C., McIntosh, N. L., McCauley, E. P., Media, J., Maheshwari, M., Valeriote, F. A., Shaw, J., & Crews, P. (2020). Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration. ACS Medicinal Chemistry Letters, 11. https://doi.org/10.1021/acsmedchemlett.9b00302

Johnson, TA, Morris, JD, Coppage, D, Cook, CV, Persi, L, Ogarrio, MA, Garcia, TC, McIntosh, NL, McCauley, EP, Media, J, Maheshwari, M, Valeriote, FA, Shaw, J & Crews, P 2020, 'Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration', ACS Medicinal Chemistry Letters, vol. 11. https://doi.org/10.1021/acsmedchemlett.9b00302

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AU - Persi, Lauren

AU - Ogarrio, Marcos A.

AU - Garcia, Taylor C.

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AU - McCauley, Erin P.

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AU - Maheshwari, Mani

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