@article{c2f76b42d26d4ca8a635da89d24e3012,
title = "Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties",
abstract = "The sponge-derived polyketide macrolides fijianolides A (1) and B (2), isolaulimalide and laulimalide, have taxol-like microtubule-stabilizing activity, and the latter exhibits potent cytotoxicity. Insight on the biogeographical and phenotypic variations of Cacospongia mycofijiensis is presented that will enable a future study of the biosynthetic pathway that produces the fijianolides. In addition to fijianolides A and B, six new fijianolides, D-I (7-12), were isolated, each with modifications to the C-20 side chain of the macrolide ring. Compounds 7-12 exhibited a range of in vitro activities against HCT-116 and MDA-MB-435 cell lines. Fijianolides 8 and 10 were shown to disrupt interphase and mitotic division, but were less potent than 2. An in vivo evaluation of 2 using tumor-bearing severe combined immuno-deficiency mice demonstrated significant inhibition of growth in HCT-116 tumors over 28 days.",
keywords = "Animals, Antineoplastic Agents, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Macrolides, Mice, SCID, Models, Molecular, Neoplasm Transplantation, Porifera, Structure-Activity Relationship, Taxoids, Transplantation, Heterologous",
author = "Johnson, \{Tyler A.\} and Karen Tenney and Cichewicz, \{Robert H.\} and Morinaka, \{Brandon I.\} and White, \{Kimberly N.\} and Taro Amagata and Balanehru Subramanian and Joseph Media and Mooberry, \{Susan L.\} and Valeriote, \{Frederick A.\} and Phillip Crews",
year = "2007",
month = jul,
day = "10",
doi = "10.1021/jm070410z",
language = "American English",
volume = "50",
pages = "3795--3803",
journal = "Journal of Medicinal Chemistry",
number = "16",
}