The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells

Nicholas Lorig-Roach; Frances Hamkins-Indik; Tyler A. Johnson; Karen Tenney; Frederick A. Valeriote; Phillip Crews

doi:10.1016/j.tet.2017.11.029

The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells

Nicholas Lorig-Roach, Frances Hamkins-Indik, Tyler A. Johnson, Karen Tenney, Frederick A. Valeriote, Phillip Crews

Research output: Contribution to journal › Article › peer-review

Original language	American English
Pages (from-to)	217-223
Number of pages	7
Journal	Tetrahedron
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/j.tet.2017.11.029
State	Published - Jan 11 2018
Externally published	Yes

Funding

We thank the Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute for collection and extraction of Oceanapia sp.27. This work was supported by a grant from the NIH R01 CA47135 (P.C. and F.A.V.). We also acknowledge funding from NSF CHE1427922 for the Thermo Velos Pro electrospray ionization hybrid ion trap-orbitrap mass spectrometer and the NIH 1S10OD018455-01 for the 800 MHz NMR spectrometer and helium cryoprobe. Finally, we thank the members of the Lokey research group at UCSC, especially M. Naylor and J. Schwochert, for their kind advice during the synthetic portion of this work.

Funders	Funder number
National Science Foundation	1S10OD018455-01, CHE1427922
National Institutes of Health	R01 CA47135

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

PANC-1 cytotoxicity
Sponge-derived halogenated indoles
Synthetic halogenated indoles

Disciplines

Biochemistry
Natural Products Chemistry and Pharmacognosy

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10.1016/j.tet.2017.11.029

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title = "The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells",

keywords = "PANC-1 cytotoxicity, Sponge-derived halogenated indoles, Synthetic halogenated indoles",

author = "Nicholas Lorig-Roach and Frances Hamkins-Indik and Johnson, \{Tyler A.\} and Karen Tenney and Valeriote, \{Frederick A.\} and Phillip Crews",

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AU - Johnson, Tyler A.

AU - Tenney, Karen

AU - Valeriote, Frederick A.

AU - Crews, Phillip

PY - 2018/1/11

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KW - Sponge-derived halogenated indoles

KW - Synthetic halogenated indoles

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The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells

Funding

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

OpenUrl availability

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